Job advertisement from January 30th, 2018   vacancy from: January 30th, 2018
Institut für Molekulare Onkologie (AG Bastians)

The laboratory for Cellular Oncology of Prof. Holger Bastians, PhD seeks to appoint a

PhD student in molecular cancer research (m/f)
limited for 3 years, part-time | salary according to TV-L

Topic: Molecular and cell biological mechanisms of genome instability and signal transduction pathways in cancer cells. Unraveling the molecular links between structural and numerical chromosome aberrations in cancer.

Our lab has a long-standing expertise and interest in the analyses of genome dynamics and the investigation of chromosome segregation and aneuploidy in human cancer cells. The evolvement of structural and numerical chromosome aberrations (known as genome instability) is key to tumor evolution and can contribute to tumorigenesis, tumor progression and the development of therapy resistance. Therefore, it is of utmost interest to unravel the molecular mechanisms underlying the generation of genome instability in human cancer cells.

For the planned project, we are particularly interested in investigating different highly tumor relevant signal transduction pathways that might be involved in the generation of genome instability. We are also highly interested in the investigation of molecular mechanisms that link structural and numerical chromosome aberrations in cancer cells.

Methods in our lab include various human tissue cultures, cell manipulations (CRISPR/Cas9, plasmid expression, siRNA, shRNA, transduction), FACS, microscopy (live cell microscopy, deconvolution microscopy) and additional state-of-the-art cell and molecular and biochemical techniques.

Examples of our previous work (pfds are available upon request):

  • Stolz et al., Nature Cell Biology 2010
  • Ertych et al., Nature Cell Biology 2014
  • Ertych et al. PNAS 2016
  • Lüddecke et al., Oncogene 2016
  • Stolz et al., Cell Cycle 2015
  • Stolz et al. EMBO Reports 2015

We are searching for a highly motivated and enthusiastic candidate (m/f) with great interest in cell/molecular biology research, which is of high medical relevance.

The candidate should hold a very good Master degree in Biology, Biochemistry, Molecular Medicine, Human Biology, or related areas. Experience in human tissue culture, transfections, microscopy and knowledge in tumor biology/signal transduction is a plus. Candidates that have not yet obtained a master degree are also invited to apply.

It is expected that successful candidates become part of a structured graduate school established in Göttingen. This will include the opportunity to attend to scientific and professional skill courses, attend international conferences and receive career development services. The Ph.D. student will be supported by a thesis advisory committee.

Further information can be found in the internet for the graduate programs in Molecular Medicine ( and the Göttingen Graduate School for Neuroscience, Biophysics and Molecular Biosciences (GGNB;

Starting date of the position is as soon as possible, but can be arranged individually.

The position is fully funded by the DFG according to the german TV-L system.

Please send your full application containing your CV, description of your technical experience, a letter of motivation, copies of bachelor and master certificates, list of publications and the names and addresses of two referees to:

Women are especially encouraged to apply. Applicants with disabilities and equal qualifications will be given preferential treatment.

We look forward to receiving your application by February 28th, 2018

University Medical Center Göttingen
Institut für Molekulare Onkologie (AG Bastians)
Prof. Dr. Holger Bastians
Grisebachstr. 8
37077 Göttingen
Tel.: 0551/39-33823

Please send your application only via e-mail as a PDF-file.

Travel and application fees cannot be refunded or transferred.